S-2-Azetidinecarboxylic acid hydrochloride - Names and Identifiers
S-2-Azetidinecarboxylic acid hydrochloride - Physico-chemical Properties
Molecular Formula | C4H8ClNO2
|
Molar Mass | 137.565 |
Boling Point | 268.5°C at 760 mmHg |
Flash Point | 116.2°C |
Vapor Presure | 0.00218mmHg at 25°C |
S-2-Azetidinecarboxylic acid hydrochloride - Introduction
(2S)-azetidine-2-carboxylic acid hydrochloride ((2S)-azetidine-2-carboxylic acid hydrochloride) is an organic compound with the chemical formula C5H9NO2 · HCl. The following is a description of its nature, use, preparation and safety information:
Nature:
(2S)-azetidine-2-carboxylic acid hydrochloride is a white crystalline powder, soluble in water and alcohol solvents. It is optically active and has a left-handed nature.
Use:
(2S)-azetidine-2-carboxylic acid hydrochloride is commonly used as a chiral inducer and catalyst in organic synthesis. It can be used in the preparation of chiral drugs, hormones and natural products.
Method:
(2S)-azetidine-2-carboxylic acid hydrochloride can be prepared by the following steps:
1. First, (2S)-alanine is reacted with ammonium bicarbonate to generate 2-aminopropionate;
2. Then, condensation of 2-aminopropionate with acetaldehyde and dehydration to produce 2-butylaminopropanol;
3. Finally, 2-butylaminopropanol hydrochloride is reacted with HCl to obtain the final product (2S)-azetidine-2-carboxylic acid hydrochloride.
Safety Information:
When using (2S)-azetidine-2-carboxylic acid hydrochloride, you need to pay attention to the following safety precautions:
1. It is an organic compound, which is irritating and corrosive. Direct contact with skin, eyes and respiratory tract should be avoided.
2. During use, you need to take good ventilation measures and wear appropriate personal protective equipment, such as gloves, goggles and protective masks.
3. Storage should be sealed, away from fire, heat and oxidant.
4. In case of accidental contact or inhalation, rinse immediately with plenty of water and seek the help of medical personnel.
Last Update:2024-04-09 21:01:54